38. DO NMDAR ANTIBODIES CAUSE SCHIZOPHRENIA?

Do anti-ganglioside antibodies cause human peripheral neuropathies?

CSF IgA NMDAR antibodies are potential biomarkers for teratomas in anti-NMDAR encephalitis

OBJECTIVE To evaluate the presence of immunoglobulin A (IgA) subtype of anti-NMDA receptor (NMDAR) antibodies (IgA-NMDAR-Abs) in the CSF of patients with immunoglobulin G (IgG)-NMDAR-Ab encephalitis and to describe the potential association with a specific clinical pattern. METHODS The retrospective analysis for the presence of IgA-NMDAR-Abs in 94 CSF samples from patients with anti-NMDAR enc...

ELOVL5 mutations cause spinocerebellar ataxia 38.

Spinocerebellar ataxias (SCAs) are a heterogeneous group of autosomal-dominant neurodegenerative disorders involving the cerebellum and 23 different genes. We mapped SCA38 to a 56 Mb region on chromosome 6p in a SCA-affected Italian family by whole-genome linkage analysis. Targeted resequencing identified a single missense mutation (c.689G>T [p.Gly230Val]) in ELOVL5. Mutation screening of 456 i...

The role of NMDAR antibody in the etiopathogenesis of schizophrenia

Many authors have reported the presence of serum NMDAR antibodies in varying proportions of patients with schizophrenia; however, many others have not been able to confirm this. Because of the contradictory findings reported in various studies, more definitive research on this issue is required. Hence, we have investigated the NR1 subunit of NMDAR antibodies in patients with schizophrenia (n=49...

Anti-NMDAR antibodies as a new piece in schizophrenia’s puzzle

Schizophrenia is a chronic psychiatric disorder marked by psychotic symptoms (i.e., hallucinations and delusions), behavioral changes (e.g., apathy, social withdrawal) and cognitive dysfunction (e.g., executive impairment) [1]. Affecting roughly 1% of the general population, schizophrenia exerts a significant socioeconomic burden due to its severity. From an etiopathogenic perspective, schizoph...